Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Background: A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China in late
2019. This virus rapidly spread around the world causing disease ranging from minimal …

A 27-year-old patient with a history of severe obstetrical complications and arterial
thrombosis received a diagnosis of hereditary thrombotic thrombocytopenic purpura (TTP) …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal
thrombotic microangiopathy caused by autoantibody-mediated severe deficiency of …

Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In
immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet …

Background Congenital thrombotic thrombocytopenic purpura (TTP) results from severe
hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and …