Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

During DNA repair by homologous recombination (HR), DNA synthesis copies information
from a template DNA molecule. Multiple DNA polymerases have been implicated in repair …

Homologous recombination (HR) is a central process to ensure genomic stability in somatic
cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity …

Coordination between DNA replication and DNA repair ensures maintenance of genome
integrity, which is lost in cancer cells. Emerging evidence has linked homologous …

The RecQ family of DNA helicases is highly conserved throughout evolution, and is
important for the maintenance of genome stability. In humans, five RecQ family members …

Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR),
a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay …

Homologous recombination (HR) is a major mechanism for eliminating DNA double-strand
breaks from chromosomes. In this process, the break termini are resected nucleolytically to …