The success of immunotherapy relies on the participation of all arms of the immune system
and the role of CD4+ T lymphocytes in preventing tumor growth is now well established …

Gamma-interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in
most antigen presenting cells and is interferon γ inducible in other cell types via signal …

Commensal gut microbiota–host immune responses are experimentally delineated via
gnotobiotic animal models or alternatively by antibiotic perturbation of gut microbiota …

Although it is known that lysosomal cysteine cathepsins require a reducing environment for
optimal activity, it is not firmly established how these enzymes are maintained in their …

Spinal cord injury (SCI) is a complex debilitating condition leading to permanent life-long
neurological deficits. The complexity of SCI suggests that a concerted multi-targeted …

Background: Osteosarcoma (OS) is the most common primary bone tumour in children and
adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic …

Given the possible critical importance of placental gene imprinting and random monoallelic
expression on fetal and infant health, most of those genes must be identified, in order to …

Redox regulation is critical for a number of cellular functions and has been implicated in the
etiology and progression of several diseases, such as cardiovascular diseases …

Spinal cord injury (SCI) is associated with devastating neurological deficits affecting more
than 11,000 Americans each year. Although several therapeutic agents have been …

Tumor immunosurveillance is known to be of critical importance in controlling tumorigenesis
and progression in various cancers. The role of gamma-interferon-inducible lysosomal thiol …