The human periconceptional maternal-embryonic space in health and disease

I Moreno, A Capalbo, A Mas… - Physiological …, 2023 - journals.physiology.org
Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …

[HTML][HTML] Exosomes: New regulators of reproductive development

C Chen, Z Zhang, X Gu, X Sheng, L Xiao, X Wang - Materials Today Bio, 2023 - Elsevier
Exosomes are a subtype of extracellular vesicles (EVs) with a size range between 30 and
150​ nm, which can be released by the majority of cell types and circulate in body fluid …

The role of microRNAs in human embryo implantation: a review

ABM Paul, ST Sadek, AM Mahesan - Journal of assisted reproduction and …, 2019 - Springer
MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we
present here a review of the literature from a clinical perspective. Implantation involves …

Current advancements in noninvasive profiling of the embryo culture media secretome

R Zmuidinaite, FI Sharara, RK Iles - International Journal of Molecular …, 2021 - mdpi.com
There have been over 8 million babies born through in vitro fertilization (IVF) and this
number continues to grow. There is a global trend to perform elective single embryo …

[HTML][HTML] MicroRNAs in combined spent culture media and sperm are associated with embryo quality and pregnancy outcome

M Abu-Halima, ZA Khaizaran, BM Ayesh, U Fischer… - Fertility and sterility, 2020 - Elsevier
Objective To identify differentially abundant miRNAs in sperm samples and spent culture
media (SCM) of embryos of different grade toward a prediction of pregnancy outcome …

Secreted MicroRNA to predict embryo implantation outcome: from research to clinical diagnostic application

W Zhou, E Dimitriadis - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Embryo implantation failure is considered a leading cause of infertility and a significant
bottleneck for in vitro fertilization (IVF) treatment. Confirmed factors that lead to implantation …

Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation

D Cimadomo, L Rienzi, A Giancani, E Alviggi… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Can miRNAs be reliably detected in the spent blastocyst media
(SBM) after IVF as putative biomarkers of the implantation potential of euploid embryos …

Extracellular vesicles, microRNA and the preimplantation embryo: non-invasive clues of embryo well-being

DC Hawke, AJ Watson, DH Betts - Reproductive BioMedicine Online, 2021 - Elsevier
Elective single embryo transfer is rapidly becoming the standard of care in assisted
reproductive technology for patients under the age of 35 years with a good prognosis …

MicroRNAs, small regulatory elements with significant effects on human implantation: a review

E Azizi, ZS Mofarahe, M Naji - Journal of Assisted Reproduction and …, 2023 - Springer
Embryo implantation is a critical process for achieving a successful pregnancy and live birth.
The proper implantation must have a synchronized interaction between blastocyst and a …

Endometrial microRNAs and their aberrant expression patterns

S Tamaru, T Kajihara, Y Mizuno, Y Mizuno… - Medical Molecular …, 2020 - Springer
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression.
They play fundamental roles in several biological processes, including cell differentiation …