Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Combinatorial and sequential targeted therapy in metastatic renal cell carcinoma

MR Matrana, BJ Atkinson, NM Tannir - Kidney Cancer: Principles and …, 2015 - Springer
Greater insight into the biology of renal cell carcinoma (RCC) has expanded treatment
options in metastatic RCC (mRCC). Since 2005, seven targeted agents have been approved …