Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

The objective of the present study was to review the current knowledge regarding the
bioaccumulation potential of ionizable organic compounds (IOCs), with a focus on the …

Body surface area (BSA) scaling has been used for prescribing individualized dosages of
various drugs and has also been recommended by the US Food and Drug Administration as …

The aim of this study was to evaluate different physiologically based modeling strategies for
the prediction of human pharmacokinetics. Plasma profiles after intravenous and oral dosing …

Generic PBPK models, applicable to a large number of substances, coupled to parameter
databases and QSAR modules, are now available for predictive modelling of inter-individual …

This review summarizes the most recent developments in and applications of physiologically
based pharmacokinetic (PBPK) modeling methodology originating from both the …

The concept of physiologically based pharmacokinetic (PBPK) modeling was introduced
years ago, but it has not been practiced significantly. However, interest in and …

We systematically validated a robust 96-well Caco-2 assay via an extended set of 93
marketed drugs with diverse transport mechanisms and quantified by LC/MS/MS, to …

Early prediction of human clearance is often challenging, in particular for the growing
number of low-clearance compounds. Long-term in vitro models have been developed …

Allometric scaling is widely used to predict human pharmacokinetic parameters from
preclinical species, and many different approaches have been proposed over the years to …