Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and
BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 …

Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …

Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …

LINE-1s are active human DNA parasites that are agents of genome dynamics in evolution
and disease. These streamlined elements require host factors to complete their life cycles …

Summary Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome
and are its only active autonomous retrotransposons. However, the host factors that regulate …

LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …

Abstract Long interspersed element-1 (LINE-1, or L1) is the only autonomous
retrotransposon that is active in human cells. Different host factors have been shown to …

The number of software tools available for detecting transposable element insertions from
whole genome sequence data has been increasing steadily throughout the last~ 5 years …