The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …

The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

Rates of spontaneous mutation critically determine the genetic diversity and evolution of
RNA viruses. Although these rates have been characterized in vitro and in cell culture …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has
facilitated the study of viral genome evolution over a brief period of time. This has …

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA
cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this …

Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …

ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …

Abstract Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are
particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity …