Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of
tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted …

Segregation is a common problem in batch-based direct compression (BDC) processes,
especially with low-dose tablet products, as is the preparation of a homogenous mixture …

Inverse gas chromatography (IGC) is presented as an technique useful for characterization
of both surface and bulk properties of various materials within the wide range of temperature …

Spherical crystallization can be an important technological step in the production of a solid
form active agent. By the production of spherical crystals, direct compression tablet making …

We report here on improved uniformity of blends of micronised active pharmaceutical
ingredients (APIs) using addition of spherical agglomerates of lactose and enhanced blend …

Manufacture of low-dose tablet products has always the uniformity challenge. The objective
of this work was to investigate the influence of key process variables of a gentle-wing high …

МІНІСТЕРСТВО ОХОРОНИ ЗДОРОВ'Я УКРАЇНИ Page 1 Міністерство охорони здоров’я
України Національний фармацевтичний університет Міністерство охорони здоров’я …

The pharmaceutical industry relies heavily on batch-based tablet manufacturing. However,
the experiences from other industrial fields strongly indicate that a switch toward continuous …

Continuous manufacturing for pharmaceutical solid dosage forms has reached a significant
milestone over the past decade due to efforts from academia, industry, and regulatory …

2 n–liczba poziomów zmiennych niezależnych w planie czynnikowym, MCC–celuloza
mikrokrystaliczna (ang. microcrystalline cellulose) MM–średni kwadrat (ang. Mean Square) …