Metabolomics is a branch of 'omics' sciences that utilises a couple of analytical tools for the
identification of small molecules (metabolites) in a given sample. The overarching goal of …

Cancer cells voraciously consume nutrients to support their growth, exposing metabolic
vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular …

Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as powerful
drugs that can be used to treat heart failure (HF) patients, both with preserved and reduced …

Aims It is unclear whether higher triglyceride metabolism per se contributes to mortality
separate from elevated triglyceride-rich lipoproteins and body mass index. This study tested …

Background Inflammation and protein energy malnutrition are associated with heart failure
(HF) mortality. The metabolic vulnerability index (MVX) is derived from markers of …

The dysregulation of cellular metabolism is a hallmark of ageing. To understand the
metabolic changes that occur as a consequence of the ageing process and to find …

Background Chronic disease, such as heart failure, influences cellular metabolism and
shapes circulating metabolites. The relationships between key energy metabolites and …

Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …

Despite significant advances in medical treatments and drug development, atherosclerotic
cardiovascular disease (ASCVD) remains a leading cause of death worldwide …

Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for
various biological functions and is associated with longevity. Phosphatidylethanolamine N …