TET (Ten-eleven translocation) family proteins: structure, biological functions and applications

X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Role of natural and synthetic compounds in modulating NRF2/KEAP1 signaling pathway in prostate cancer

G Tossetta, S Fantone, D Marzioni, R Mazzucchelli - Cancers, 2023 - mdpi.com
Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer

T Lan, S Arastu, J Lam, H Kim, W Wang, S Wang… - Nature …, 2024 - nature.com
Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat
oxidative stress and support reductive biosynthesis. One major NADPH production route is …

Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy

L Palanivelu, CH Liu, LT Lin - Frontiers in Immunology, 2023 - frontiersin.org
According to the World Health Organization, cancer is one of the leading global health
concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics …

Hydrogen therapy and its future prospects for ameliorating COVID-19: clinical applications, efficacy, and modality

I Perveen, B Bukhari, M Najeeb, S Nazir, TA Faridi… - Biomedicines, 2023 - mdpi.com
Molecular hydrogen is renowned as an odorless and colorless gas. The recommendations
developed by China suggest that the inhalation of hydrogen molecules is currently advised …

[HTML][HTML] Nano-vitamin C: A promising candidate for therapeutic applications

T Bedhiafi, S Idoudi, Q Fernandes, L Al-Zaidan… - Biomedicine & …, 2023 - Elsevier
Vitamin C is an important nutrient implicated in different physiological functions in humans.
Despite its important biological functions, therapeutic applications of vitamin C are rare and …

[HTML][HTML] Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy

S Isola, L Gammeri, F Furci, S Gangemi… - International Journal of …, 2024 - mdpi.com
Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory,
immunoregulatory, and antioxidant activities. Today, this vitamin is integrated into the …

Bioactive vitamin C content from natural selected fruit juices

M Feszterová, M Mišiaková, M Kowalska - Applied Sciences, 2023 - mdpi.com
The content of vitamin C in fruit juices can be lowered by alterations in storage and
temperature. This study compared storage circumstances (temperature, duration, and …

The NF-κB transcriptional network is a high-dose vitamin C-targetable vulnerability in breast cancer

A Mussa, HA Afolabi, NH Syed, M Talib, AH Murtadha… - Biomedicines, 2023 - mdpi.com
Breast cancer (BC) is the most common cancer type among women with a distinct clinical
presentation, but the survival rate remains moderate despite advances in multimodal …

Role of vitamin C in targeting cancer stem cells and cellular plasticity

Y Lee - Cancers, 2023 - mdpi.com
Simple Summary This review is centered on the potential therapeutic utility of vitamin C (VC)
in the context of dynamic cancer evolution. Physiologically, VC has dose-dependent roles as …