Multicomponent reactions (MCRs) are extremely popular owing to their facile execution,
high atom-efficiency and the high diversity of products. MCRs can be used to access various …

Sustainable or green chemistry has established firm ground providing essential design
criteria for the development of efficient chemical syntheses of complex, high added value …

Multicomponent reactions (MCRs) are remarkable one-pot combinatorial synthetic tools
involving at least three reactants whose nearly all atoms are incorporated in the final …

The impressive success in the synthesis of novel products via sustainable and green
methods is a crucial purpose in organic synthesis. Water as a “green solvent” plays a vital …

The total syntheses of selected natural products using different versions of the Ugi
multicomponent reaction is reviewed on a case-by-case basis. The revision covers the …

Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of
isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide …

The Ugi three component reaction (U‐3CR) is a variation of the famous Ugi reaction,
discovered almost 60 years ago. Today it is somehow neglected, compared to the classical …

A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived
phosphoric acid with bulky 2, 4, 6-tricyclohexylphenyl groups at the 6, 6′ positions was …

The catalytic activity of urea-, metal-and organic acid-based/choline chloride deep eutectic
solvents/organocatalysts was investigated for the synthesis of 3-aminoimidazo-fused …

The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole
synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to …