Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …

In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells
(VSMCs) in a" contractile" phenotype are required for the normal regulation of vascular tone …

Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac
muscle and smooth muscle through direct contacts with serum response factor (SRF) over …

Extracellular matrix (ECM) within the vascular network provides both a structural and
regulatory role. The ECM is a dynamic composite of multiple proteins that form structures …

Smooth muscle cells (SMC) are the major cell type in blood vessels. Their principal function
in the body is to regulate blood flow and pressure through vessel wall contraction and …

Abstract Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical
modulators of phenotypic changes associated with physiological and pathological contexts …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …