Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …