Dynamics and specificities of T cells in cancer immunotherapy

G Oliveira, CJ Wu - Nature Reviews Cancer, 2023 - nature.com
Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

High-throughput and single-cell T cell receptor sequencing technologies

JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients

SK Saini, DS Hersby, T Tamhane, HR Povlsen… - Science …, 2021 - science.org
T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data

A Montemurro, V Schuster, HR Povlsen… - Communications …, 2021 - nature.com
Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

TR Müller, T Sekine, D Trubach, J Niessl… - Science translational …, 2023 - science.org
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in
individuals with various immunodeficiencies. Given the increased antibody evasion …

Promises and challenges of adoptive T-cell therapies for solid tumours

M Morotti, A Albukhari, A Alsaadi, M Artibani… - British journal of …, 2021 - nature.com
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …

Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening

H Huang, C Wang, F Rubelt, TJ Scriba… - Nature …, 2020 - nature.com
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …

Cancer neoantigens

TN Schumacher, W Scheper… - Annual review of …, 2019 - annualreviews.org
Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium

DV Bagaev, RMA Vroomans, J Samir… - Nucleic acids …, 2020 - academic.oup.com
Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …

Antitumour dendritic cell vaccination in a priming and boosting approach

A Harari, M Graciotti, M Bassani-Sternberg… - Nature Reviews Drug …, 2020 - nature.com
Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …