The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

Vibrational circular dichroism (VCD) spectroscopy is one of the most powerful techniques for
the determination of absolute configurations (AC), as it does not require any specific UV/vis …

The development of synthetic methodology allowing for a strategic incorporation of fluorine
into target compounds is in a high demand in many areas of the chemical and …

Benchmarking functionals and basis sets for the computational prediction of molecular
properties is usually done on very small model systems. Larger organic molecules …

Mannich-type addition of 1, 3-dicarbonyl compounds to (SS)-N-tert-
butanesulfinyltrifluoroacetaldimine has been carried out under dramatically different …

The VCD spectra of several chiral compounds containing the CF3 group are reviewed and
analyzed. The list of compounds contains pharmaceutically relevant molecules as well as …

The Pictet–Spengler reaction is one of the important methodological arsenals in synthetic
and medicinal chemistry, acting as an amenable tool for preparing tetrahydroisoquinoline …

Taking into account the postulated reaction mechanism for the organocatalytic epoxidation
of electron-poor olefins developed by our laboratory, we have investigated the key factors …

Herein we present a rearomative diastereoselective etherification/amination reaction of 2, 3,
9, 9a-tetrahydro-1H-carbazoles, themselves accessible via the Diels-Alder reaction of N …