Liquid biopsy for lung cancer: up-to-date and perspectives for screening programs

GMS Casagrande, MO Silva, RM Reis… - International Journal of …, 2023 - mdpi.com
Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

[HTML][HTML] The role of liquid biopsy in early diagnosis of lung cancer

C Freitas, C Sousa, F Machado, M Serino… - Frontiers in …, 2021 - frontiersin.org
Liquid biopsy is an emerging technology with a potential role in the screening and early
detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and …

A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma

F Xu, H Lin, P He, L He, J Chen, L Lin, Y Chen - Oncoimmunology, 2020 - Taylor & Francis
The tumor-suppressor gene tumor protein p53 (TP53) is one of the most commonly mutated
genes in human lung cancer, and TP53 mutations are associated with a worsened …

Analysis of lung adenocarcinoma subtypes based on immune signatures identifies clinical implications for cancer therapy

F Xu, J Chen, X Yang, X Hong, Z Li, L Lin… - Molecular Therapy …, 2020 - cell.com
Lung cancer is the most common cause of cancer deaths worldwide, and lung
adenocarcinoma (LUAD) is the most common histological subtype. However, the prognostic …

[HTML][HTML] A signature of immune-related gene pairs predicts oncologic outcomes and response to immunotherapy in lung adenocarcinoma

F Xu, X Zhan, X Zheng, H Xu, Y Li, X Huang, L Lin… - Genomics, 2020 - Elsevier
In this study, we established the predictive model for lung adenocarcinoma (LUAD)
depending on immune-related gene pairs (IRGPs) signature, which could not consider the …

Circulating nucleosomes and nucleosome modifications as biomarkers in cancer

P McAnena, JAL Brown, MJ Kerin - Cancers, 2017 - mdpi.com
Traditionally the stratification of many cancers involves combining tumour and
clinicopathological features (eg, patient age; tumour size, grade, receptor status and …

Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma

F Xu, H Zhang, J Chen, L Lin, Y Chen - International immunopharmacology, 2020 - Elsevier
Lung cancer is the leading reason of cancer-related death from cancer globally for both men
and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical …

Liquid biopsy and PCR-free ultrasensitive detection systems in oncology

A Finotti, M Allegretti, J Gasparello… - International …, 2018 - spandidos-publications.com
In oncology, liquid biopsy is used in the detection of next-generation analytes, such as tumor
cells, cell-free nucleic acids and exosomes in peripheral blood and other body fluids from …

[HTML][HTML] DNA methylation-based lung adenocarcinoma subtypes can predict prognosis, recurrence, and immunotherapeutic implications

F Xu, L He, X Zhan, J Chen, H Xu, X Huang, Y Li… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The marked heterogeneity of lung adenocarcinoma (LUAD) makes its diagnosis and
treatment difficult. In addition, the aberrant DNA methylation profile contributes to tumor …

Liquid biopsy for early diagnosis of non-small cell lung carcinoma: recent research and detection technologies

L Chang, J Li, R Zhang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Liquid biopsy, an innovative method for early diagnosis of cancer, has changed the
traditional method of diagnosing lung cancer and is considered a feasible auxiliary …