The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in
various therapeutic applications from pain to epilepsy, but its psychotropic effect has …

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in …

Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …

The corollaries of the obesity epidemic that plagues developed societies are malnutrition
and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty …

Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the
fragile X mental retardation protein, which regulates signal transduction at metabotropic …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

A long-standing literature linking endocannabinoids (ECBs) to stress, fear, and anxiety has
led to growing interest in developing novel anxiolytics targeting the ECB system. Following …