DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

PJ Hop, RAJ Zwamborn, E Hannon… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the …

FW Lohoff, TK Clarke, ZA Kaminsky, RM Walker… - Molecular …, 2022 - nature.com
Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …

[HTML][HTML] Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders

ELS Conole, K Vaher, MB Cabez, G Sullivan… - Brain, Behavior, and …, 2023 - Elsevier
Background Preterm birth is closely associated with a phenotype that includes brain
dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of …

Associations of alcohol consumption with epigenome‐wide DNA methylation and epigenetic age acceleration: individual‐level and co‐twin comparison analyses

M Stephenson, S Bollepalli, E Cazaly… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background DNA methylation may play a role in the progression from normative to
problematic drinking and underlie adverse health outcomes associated with alcohol misuse …

[HTML][HTML] Inference of tobacco and alcohol consumption habits from DNA methylation analysis of blood

A Ambroa-Conde, MAC de Cal, A Gómez-Tato… - Forensic Science …, 2024 - Elsevier
DNA methylation has become a biomarker of great interest in the forensic and clinical fields.
In criminal investigations, the study of this epigenetic marker has allowed the development …

Validating biomarkers and models for epigenetic inference of alcohol consumption from blood

SCE Maas, A Vidaki, A Teumer, R Costeira, R Wilson… - Clinical …, 2021 - Springer
Background Information on long-term alcohol consumption is relevant for medical and public
health research, disease therapy, and other areas. Recently, DNA methylation-based …

DNA methylation analysis for smoking status prediction in the Chinese population based on the methylation-sensitive single-nucleotide primer extension method

D Wen, J Shi, Y Liu, W He, W Qu, C Wang… - Forensic Science …, 2022 - Elsevier
In some criminal cases, the identity of suspect is unknown and there is no matching DNA
profile in the DNA database. Forensic DNA Phenotyping can provide useful investigative …

DNA methylation changes associated with cannabis use and verbal learning performance in adolescents: an exploratory whole genome methylation study

M Wiedmann, S Kuitunen-Paul, LA Basedow… - Translational …, 2022 - nature.com
The association between extent of chronic cannabis use (CCU-extent) and cognitive
impairment among adolescents has been the subject of controversial debate. Linking DNA …

Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study

M Lu, Q Xueying, P Hexiang, G Wenjing, S Hägg… - …, 2021 - Taylor & Francis
Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the
association between alcohol and disease, but limited number of positive CpG sites …