Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

Background Patients infected with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …

Conventional genetic testing of individuals with neurodevelopmental presentations and
congenital anomalies (ND/CAs), ie, the analysis of sequence and copy number variants …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic
mechanism. However, it has been proven that the key underlying risk factor is a genetic …