Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease

M Nieto, M Konigsberg, A Silva-Palacios - Biogerontology, 2024 - Springer
Cellular senescence is characteristic of the development and progression of multiple age-
associated diseases. Accumulation of senescent cells in the heart contributes to various age …

Targeting cardiomyocyte cell cycle regulation in heart failure

C Zhu, T Yuan, J Krishnan - Basic Research in Cardiology, 2024 - Springer
Heart failure continues to be a significant global health concern, causing substantial
morbidity and mortality. The limited ability of the adult heart to regenerate has posed …

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

LP Wong, H Alias, KM Tan, PF Wong… - Frontiers in …, 2023 - frontiersin.org
Objective: The field of targeting cellular senescence with drug candidates to address age-
related comorbidities has witnessed a notable surge of interest and research and …

Open Library of Bioscience

I Nieto, M Velasco, C Miranda - ngdc.cncb.ac.cn
Cellular senescence is characteristic of the development and progression of multiple age-
associated diseases. Accumulation of senescent cells in the heart contributes to various age …