ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Roles of apoE4 on the pathogenesis in Alzheimer's disease and the potential therapeutic approaches

YY Sun, Z Wang, HC Huang - Cellular and molecular neurobiology, 2023 - Springer
Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …

Association between the self-reported duration and quality of sleep and cognitive function among middle-aged and older adults in China

M Li, N Wang, ME Dupre - Journal of Affective Disorders, 2022 - Elsevier
Abstract Background The World Alzheimer Report showed that 46.8 million people suffered
from dementia in 2015. This study examined how the duration and quality of sleep are …

Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype

AA Baril, AS Beiser, E Sanchez… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We evaluated whether insomnia symptom severity was associated with
cognitive function, and whether this relationship was modified by biomarkers associated with …

Day‐to‐day sleep variability with Alzheimer's biomarkers in at‐risk elderly

AA Baril, C Picard, A Labonté… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Measuring day‐to‐day sleep variability might reveal unstable sleep‐wake
cycles reflecting neurodegenerative processes. We evaluated the association between …

Poor diet, long sleep, and lack of physical activity are associated with inflammation among non-demented community-dwelling elderly

M Basta, C Belogianni, M Yannakoulia, I Zaganas… - Healthcare, 2022 - mdpi.com
Inflammation in elderly is associated with physical and cognitive morbidity and mortality. We
aimed to explore the association of modifiable lifestyle parameters with inflammation among …

The relationship between sleep disturbance and apolipoprotein E ε4 in adults with mild cognitive impairment and Alzheimer's disease dementia: an integrative review

W Wei, K Wang, J Shi, Z Li - Biological Research for Nursing, 2022 - journals.sagepub.com
Background Apolipoprotein E ε4 (APOE ε4) was shown to be a risk factor for mild cognitive
impairment (MCI) and Alzheimer's disease (AD) dementia. When coupled with sleep …

Cretan aging cohort-phase III: methodology and descriptive characteristics of a long-term longitudinal study on predictors of cognitive decline in non-demented elderly …

M Basta, E Skourti, C Alexopoulou, A Zampetakis… - Healthcare, 2023 - mdpi.com
Identifying modifiable factors that may predict long-term cognitive decline in the elderly with
adequate daily functionality is critical. Such factors may include poor sleep quality and …

[HTML][HTML] Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila

RCM Moraes, JR Roth, H Mao, SR Crawley, BP Xu… - Genes, 2024 - mdpi.com
Background: Apolipoprotein E (ApoE) is the leading genetic risk factor for late-onset
Alzheimer's disease (AD), which is the leading cause of dementia worldwide. Most people …

Longitudinal associations of lipid profiles with sleep disorders in patients with Parkinson's disease

M Ye, Q Ji, Q Liu, X Kang, Y Zhan - Lipids, 2024 - Wiley Online Library
To examine the associations of apolipoprotein E (APOE) carrier status and lipid profiles with
sleep disorders, including excessive daytime sleepiness (EDS) and probable rapid eye …