In vitro–in vivo correlations: general concepts, methodologies and regulatory applications
I González-García, V Mangas-Sanjuán… - Drug development …, 2015 - Taylor & Francis
The major objective of in vitro–in vivo correlations is to be able to use in vitro data to predict
in vivo performance serving as a surrogate for an in vivo bioavailability test and to support …
in vivo performance serving as a surrogate for an in vivo bioavailability test and to support …
Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …
IVIVC for extended release hydrophilic matrix tablets in consideration of biorelevant mechanical stress
V Mohylyuk, S Goldoozian, GP Andrews… - Pharmaceutical …, 2020 - Springer
Purpose When establishing IVIVC, a special problem arises by interpretation of averaged in
vivo profiles insight of considerable individual variations in term of time and number of …
vivo profiles insight of considerable individual variations in term of time and number of …
Conventional vs Mechanistic IVIVC: A Comparative Study in Establishing Dissolution Safe Space for Extended Release Formulations
S Kollipara, T Ahmed, M Chougule, C Guntupalli… - AAPS …, 2024 - Springer
The use of in vitro-in vivo correlation (IVIVC) for extended release oral dosage forms is an
important technique that can avoid potential clinical studies. IVIVC has been a topic of …
important technique that can avoid potential clinical studies. IVIVC has been a topic of …
Convolution-and deconvolution-based approaches for prediction of pharmacokinetic parameters of diltiazem extended-release products in flow-through cell …
NF Taha, LH Emara - AAPS PharmSciTech, 2022 - Springer
The present study evaluated the effect of different configuration setups of the Flow-Through
Cell (USP IV) dissolution tester in developing in vitro–in vivo correlation (IVIVC). A …
Cell (USP IV) dissolution tester in developing in vitro–in vivo correlation (IVIVC). A …
Discriminative Power of the Flow through Cell Dissolution Tester in Predicting the In Vivo Performance of Pentoxifylline SR Product under Fed and Fasting Conditions
NF Taha, LH Emara - AAPS PharmSciTech, 2024 - Springer
This study explored, for the first time the role of different designs of the Flow-Through-Cell
(FTC, USP IV) dissolution Tester in predicting the in-vivo performance of Pentoxifylline (PTX) …
(FTC, USP IV) dissolution Tester in predicting the in-vivo performance of Pentoxifylline (PTX) …
In vivo predictive dissolution (IPD) for carbamazepine formulations: additional evidence regarding a biopredictive dissolution medium
M Bermejo, J Meulman, MG Davanço, PO Carvalho… - Pharmaceutics, 2020 - mdpi.com
The aim of the present study was to bring additional evidence regarding a biopredictive
dissolution medium containing 1% sodium lauryl sulphate (SLS) to predict the in vivo …
dissolution medium containing 1% sodium lauryl sulphate (SLS) to predict the in vivo …
Two different approaches for the prediction of In Vivo plasma concentration-time profile from In Vitro release data of once daily formulations of diltiazem …
ER Bendas - Archives of pharmacal research, 2009 - Springer
The aim of this study was to employ two different mathematical approaches: first, a
convolution approach using computer software; second, a mathematical calculation …
convolution approach using computer software; second, a mathematical calculation …
In vitro–in vivo correlations for three different commercial immediate-release indapamide tablets
P Yaro, X He, W Liu, M Xun, Y Ma, Z Li… - Drug Development and …, 2014 - Taylor & Francis
The objective of this study was to develop and validate the in vitro–in vivo correlations
(IVIVCs) of three commercially available immediate-release solid dosage forms of …
(IVIVCs) of three commercially available immediate-release solid dosage forms of …
Development of sustained release pellets of galantamine HBr by extrusion spheronization technique incorporating risk based QbD approach
HB Rana, MC Gohel, MS Dholakia… - Research journal of …, 2018 - indianjournals.com
Objective The present research aims to integrate the concept of quality by design (QbD) to
develop galantamine HBr modified release pellets and to scrutinize the critical factors that …
develop galantamine HBr modified release pellets and to scrutinize the critical factors that …