Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Pheochromocytoma represents very significant challenges to the anesthetist, especially
when undiagnosed. These chromaffin tissue tumors are not uncommon in anesthetic …

Background Vasoplegic syndrome, defined by hypotension despite normal or increased
cardiac output, is associated with high mortality rate after cardiopulmonary bypass …

Background The role of methylene blue (MB) in patients with vasodilatory shock is unclear.
The purpose of this systematic review and meta-analysis was to evaluate the efficacy and …

Objective: This study was conducted to reassess the concepts established over the past 20
years, in particular in the last 5 years, about the use of methylene blue in the treatment of …

Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the
cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to …

PURPOSE: Cardiopulmonary bypass (CPB) procedures are thought to activate systemic
inflammatory reaction syndrome (SIRS). Strategies to curb systemic inflammation have been …

Sepsis is a multisystem disease process, which constitutes a significant public health
challenge and is associated with high morbidity and mortality. Among other systems, sepsis …

In a brief overview, in NO–sGC–cGMP signaling in a blood vessel, l-arginine is converted in
the endothelium monolayer by the endothelial nitric oxide synthase (eNOS) to NO which …

Objectives The purpose of this study was to investigate whether patients who received
methylene blue as treatment for vasoplegia during cardiac surgery with cardiopulmonary …