We all have a sense of time. Yet, there are no sensory receptors specifically dedicated for
perceiving time. It is an almost uniquely intangible sensation: we cannot see time in the way …

Ketamine is a noncompetitive antagonist of N-methyl-d-asparate (NMDA) receptor and has
been long used as an anesthetic agent in humans and veterinary medicine. The present …

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …

Increasing preclinical and clinical evidence underscores the strong and rapid
antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine …

Glutamatergic neurotransmission mediated by N-methyl-d-aspartate (NMDA) receptors is
vital for the cortical computations underlying cognition and might be disrupted in severe …

Despite great advances in basic neuroscience knowledge, the improved understanding of
brain functioning has not yet led to the introduction of truly novel pharmacological …

Introduction Ketamine is attracting increasing research interest not only because of its
powerful amnestic effects but also as a putative model of schizophrenia and as a substance …

Context Ketamine evokes psychosislike symptoms, and its primary action is to impairN-
methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary …

Modulating glutamatergic neurotransmission induces alterations in conscious experience
that mimic the symptoms of early psychotic illness. We review studies that use intravenous …

Recent cognitive neuropsychiatric models of psychosis emphasize the role of attentional
disturbances and inappropriate incentive learning in the development of deLusions. These …