Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Conspectus Histidine kinases (HK) are the sensory proteins of two-component systems,
responsible for a large fraction of bacterial responses to stimuli and environmental changes …

Allosteric and transmembrane (TM) signaling are among the major questions of structural
biology. Here, we review and discuss signal transduction in four‐helical TM bundles …

The thermosensor histidine kinase DesK from B acillus subtilis senses changes in
membrane fluidity initiating an adaptive response. Structural changes in DesK have been …

The lipid bilayer component of biological membranes is important for the distribution,
organization, and function of bilayer spanning proteins. These physical barriers are …

Under anaerobic conditions, bacteria may utilize nitrates and nitrites as electron acceptors.
Sensitivity to nitrous compounds is achieved via several mechanisms, some of which rely on …

Cardiovascular diseases, neuropsychiatric disorders, and cancers seriously endanger
human health. Mechanistic and pharmacological mechanisms of candidate drugs are …

ABSTRACT The EvgS/EvgA two-component system of Escherichia coli is activated in
response to low pH and alkali metals and regulates many genes, including those for the …

The C5-dicarboxylate α-ketoglutarate (α-KG) is a preferred nutrient source for the
opportunistic pathogen Pseudomonas aeruginosa. However, very little is known about how …

Chlamydia trachomatis is an obligate intracellular bacteria that undergo dynamic
morphologic and physiologic conversions upon gaining an access to a eukaryotic cell …