Most currently available antidepressants target monoamine neurotransmitter function.
However, a purely neurotransmitter-based explanation for antidepressant drug action is …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

The gene regulatory code and grammar remain largely unknown, precluding our ability to
link phenotype to genotype in regulatory sequences. Here, using a massively parallel …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Modeling of human neuropsychiatric disorders in animals is extremely challenging given the
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …

The serotonin hypothesis of depression has played an important role in the history of
psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of …

There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …