Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

Background: The liver-derived plasma protein fetuin-A is a systemic inhibitor of ectopic
calcification. Fetuin-A stabilizes saturated mineral solutions by forming colloidal protein …

Awareness of the clinical relevance of magnesium in medicine has increased over the last
years, especially for people with chronic kidney disease (CKD), due to magnesium's role in …

The increase in prevalence and severity of vascular calcification in chronic kidney disease is
a result of complex interactions between changes in the vascular bed, mineral metabolites …

Rationale: Patients with end-stage renal disease are characterized by increased
cardiovascular and all-cause mortality because of advanced remodeling of the …

The plasma protein fetuin-A mediates the formation of protein-mineral colloids known as
calciprotein particles (CPP)–rapid clearance of these CPP by the reticuloendothelial system …

An association between high serum calcium/phosphate and cardiovascular events or death
is well-established. However, a mechanistic explanation of this correlation is lacking. Here …

Patients with chronic kidney disease (CKD) are highly susceptible to cardiovascular (CV)
complications, thus suffering from clinical manifestations such as heart failure and stroke. CV …

Calciprotein particles (CPPs), which increasingly arise in the circulation during the disorders
of mineral homeostasis, represent a double-edged sword protecting the human organism …