Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Reactive oxygen species and endothelial function in diabetes

Z Fatehi-Hassanabad, CB Chan, BL Furman - European journal of …, 2010 - Elsevier
An increasing body of evidence suggests that oxidant stress is involved in the pathogenesis
of many cardiovascular diseases, including hypercholesterolemia, atherosclerosis …

B-type natriuretic peptide: endogenous regulator of myocardial structure, biomarker and therapeutic target

RH Ritchie, AC Rosenkranz… - Current molecular …, 2009 - ingentaconnect.com
B-type natriuretic peptide (BNP), initially identified in brain tissues, is now recognized as a
key cardiac hormone. Numerous studies over the last decade have demonstrated that both …

Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms

W Zhang, F Fu, R Tie, X Liang, F Tian, W Xing, J Li… - Vasa, 2013 - econtent.hogrefe.com
Background: Endothelial dysfunction is an important factor in the pathogenesis of diabetes
related vascular complications, and acute alpha-linolenic acid (ALA) intake can increase …

Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta

CH Leo, A Joshi, JL Hart, OL Woodman - Pharmacological research, 2012 - Elsevier
The aim of the study was to investigate whether diabetes-induced oxidant stress affects the
contribution of nitroxyl (HNO) to endothelium-dependent relaxation in the rat aorta. Organ …

Diabetic neuropathy and heart failure: role of neuropeptides

A Ejaz, FW LoGerfo, L Pradhan - Expert reviews in molecular …, 2011 - cambridge.org
Cardiovascular autonomic neuropathy (CAN), in which patients present with damage of
autonomic nerve fibres, is one of the most common complications of diabetes. CAN leads to …

Effects of Kaempferia parviflora Wall. Ex Baker on endothelial dysfunction in streptozotocin-induced diabetic rats

W Malakul, S Thirawarapan, K Ingkaninan… - Journal of …, 2011 - Elsevier
AIM OF THE STUDY: The aim of the present study was to investigate an ethanolic extract of
Kaempferia parviflora (KPE) reduces oxidative stress and preserves endothelial function in …

Stem cells and diabetic cardiomyopathy: from pathology to therapy

M Liu, H Chen, J Jiang, Z Zhang, C Wang, N Zhang… - Heart failure …, 2016 - Springer
The worldwide increase trend in the prevalence of diabetes has highlighted the need for
increased research efforts into treatment options for both the disease itself and its associated …

3′, 4′-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes

CH Leo, JL Hart, OL Woodman - European journal of pharmacology, 2011 - Elsevier
Diabetes is known to cause an overproduction of reactive oxygen species (ROS),
contributing to the impairment of endothelium-dependent relaxation in microvasculature …

3′, 4′-Dihydroxyflavonol prevents diabetes-induced endothelial dysfunction in rat aorta

OL Woodman, W Malakul - Life sciences, 2009 - Elsevier
AIMS: Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We
investigated whether the antioxidant 3′, 4′-dihydroxyflavonol (DiOHF) reduces the …