Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Multi-tyrosine kinase inhibitors (MTKIs) have thus far had limited success in the treatment of
castration-resistant prostate cancer (CRPC). Here, we report a phase I–cleared orally …

Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …

Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …

Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of
AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) …

The introduction of enzalutamide and abiraterone has led to improvement in the treatment of
metastatic castration-resistant prostate cancer. However, acquired resistance to …

Autophagy is a self-degradative cellular process, involved in stress response such as
starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule …

Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …