Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …

Multi-parameter phenotypic profiling of small molecules provides important insights into their
mechanisms of action, as well as a systems level understanding of biological pathways and …

The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …

The calcium/calmodulin-dependent phosphatase calcineurin plays a central role in the
control of cardiomyocyte hypertrophy in response to pathological stimuli. Although …

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The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a
calcium sensor, integrating calcium signaling with other pathways involved in development …

Calcium release-activated calcium (CRAC) channels have been the target of drug discovery
for many years. The identification of STIM and Orai proteins as key components of CRAC …

The application of in vitro models in evaluating the toxicity of toxicants has enhanced our
limited understanding of drugs and chemical-induced toxicity. From the public perspective …

Mutations in the canonical transient receptor potential channel TRPC6 lead to an autosomal
dominant form of human kidney disease characterized histologically by focal and segmental …

Abnormal proliferation and phenotypic modulation of pulmonary artery smooth muscle cells
(PASMC) contributes to the pathogenesis of numerous cardiovascular disorders, including …