Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling
pathways in tumor cells help produce a suppressive tumor microenvironment enriched for …

Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important
effector molecule of anti-tumor immunity, capable of suppressing tumor growth through …

Cancer greatly affects the quality of life of humans worldwide and the number of patients
suffering from it is continuously increasing. Over the last century, numerous treatments have …

Based on its effects on both tumour cell intrinsic malignant properties as well as anti-tumour
immune responses, tryptophan catabolism has emerged as an important metabolic regulator …

Immune checkpoints arise from physiological changes during tumorigenesis that
reprogramme inflammatory, immunological and metabolic processes in malignant lesions …

The cytotoxic T lymphocyte antigen-4 (CTLA-4)–blocking antibody ipilimumab results in
durable responses in metastatic melanoma, though therapeutic benefit has been limited to a …

Abstract Indoleamine 2, 3-dioxygenase (IDO, also referred to as IDO1) has been
demonstrated to be a normal endogenous mechanism of acquired peripheral immune …