Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

Elongation of a short telomere depends on the action of multiple telomerase molecules,
which are visible as telomerase RNA foci or clusters associated with telomeres in yeast and …