Metallothionein: a comprehensive review of its classification, structure, biological functions, and applications

R Yang, D Roshani, B Gao, P Li, N Shang - Antioxidants, 2024 - pmc.ncbi.nlm.nih.gov
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in
nature. In addition to heavy metal detoxification, metallothionein is well known as a potent …

Advances of metallodrug-amyloid β aggregation inhibitors for therapeutic intervention in neurodegenerative diseases: Evaluation of their mechanistic insights and …

HY Khan, A Ahmad, MN Hassan, YH Khan… - Coordination Chemistry …, 2024 - Elsevier
Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis (thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer's Disease

JM Wasielewska, K Szostak, LE McInnes… - ACS chemical …, 2024 - ACS Publications
Alzheimer's disease (AD) is the most prevalent cause of dementia characterized by a
progressive cognitive decline. Addressing neuroinflammation represents a promising …

Manufacture of oligopeptides containing branched-chain amino acids from the perspective of site complementation: A combination of peptidomics and chemometrics …

J Liu, Y Wang, B Jiang, Y Chang, C Xue - Food Bioscience, 2023 - Elsevier
Target peptides containing branched-chain amino acids (BCAAs) possess various proven
physiologic functions, yet there has been a limited focus on the manufacturing processes …

[HTML][HTML] Mechanism of Metal Complexes in Alzheimer's Disease

Y Liu, J Ma, Q Zhang, Y Wang, Q Sun - International Journal of Molecular …, 2024 - mdpi.com
Alzheimer's disease (AD) is a kind of neurodegenerative diseases characterized by beta-
amyloid deposition and neurofibrillary tangles and is also the main cause of dementia …

Cellular Effects of Cationic Copper (II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties

J Vančo, Z Trávníček, T Malina, J Hošek… - …, 2024 - Wiley Online Library
A series of potassium isothiocyanato‐(N‐salicylidene‐aminoacidato) cuprates (1–5) with the
general formula of the monomeric unit K [Cu (sal‐aa)(NCS)]⋅ xH2O (x= 0 or 2), containing a …

[HTML][HTML] Targeting Alzheimer's disease with novel dual-function 3, 5-diaryl-4, 5-dihydro-1H-pyrazole-1-carbothioamide derivatives

A Katsogiannou, D Karta, A Di Stefano, S Oner… - European Journal of …, 2024 - Elsevier
In the field of medicinal chemistry, the versatility of the thiosemicarbazone scaffold makes it a
promising platform for the development of next-generation pharmaceuticals. In this paper the …

Additive Effects of Cu-ATSM and Radiation on Survival of Diffuse Intrinsic Pontine Glioma Cells

SA King, SR Solst, CH Graham, LZ Fiore… - Radiation …, 2024 - meridian.allenpress.com
Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive and treatment-resistant
childhood primary brainstem tumors with a median survival of less than one year after …

Antioxidant and Antibacterial Screening and Hg (II) Sensing, Activities of Cu (II) pyridine‐2, 6‐dicarboxylate Complexes

H Ur Rahman, E Khan, M Muhammad, M Khan… - …, 2024 - Wiley Online Library
In this study five different complexes of Cu (II) were synthesized for the purpose of
environmentally notorious mercury sensing and preliminary biological screening. Pyridine …

Facile synthesis of stilbene-derivatized Schiff base ligands and their Cu (II) complexes

D Uehara, P Salas - Tetrahedron Letters, 2023 - Elsevier
Herein we present the synthesis and characterization of three Schiff base ligands
derivatized with stilbene groups and their Cu (II) complexes CuL 1-3, prepared in only three …