Metabolic Syndrome: Lessons from Rodent and Drosophila Models

MV Vatashchuk, MM Bayliak, VV Hurza… - BioMed Research …, 2022 - Wiley Online Library
Overweight and obesity are health conditions tightly related to a number of metabolic
complications collectively called “metabolic syndrome”(MetS). Clinical diagnosis of MetS …

Decoding the connection between lncRNA and obesity: Perspective from humans and Drosophila

DD Aggarwal, P Mishra, G Yadav, S Mitra, Y Patel… - Heliyon, 2024 - cell.com
Background Obesity is a burgeoning global health problem with an escalating prevalence
and severe implications for public health. New evidence indicates that long non-coding …

Deficiency of Brummer lipase disturbs lipid mobilization and locomotion, and impairs reproduction due to defects in the eggshell ultrastructure in the insect vector …

DS Arêdes, T Rios, LF Carvalho-Kelly, V Braz… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Rhodnius prolixus is a hematophagous insect, which feeds on large and infrequent blood
meals, and is a vector of trypanosomatids that cause Chagas disease. After feeding, lipids …

The remoulding of dietary effects on the fecundity/longevity trade-off in a social insect

V Rau, T Flatt, J Korb - BMC genomics, 2023 - Springer
Background In many organisms increased reproductive effort is associated with a shortened
life span. This trade-off is reflected in conserved molecular pathways that link nutrient …

Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the …

D Golubev, E Platonova, N Zemskaya, O Shevchenko… - Biogerontology, 2024 - Springer
Worldwide the aging population continues to increase, so the concept of healthy longevity
medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits …

Drosophila Lipase 3 mediates the metabolic response to starvation and aging

L Hänschke, C Heier, SJ Maya Palacios, HE Özek… - Frontiers in …, 2022 - frontiersin.org
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes
cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman …

Transcriptomic analysis of Mythimna separata ovaries and identification of genes involved in reproduction

J Fu, L Li, C Dai, Y Zhang, Y Hu, C Hu, H Li - … Biochemistry and Physiology …, 2023 - Elsevier
The migratory insect Mythimna separata is a major pest of grain crops in Asia. Unfortunately,
the molecular mechanisms that control and regulate reproduction in this species remain …

An important role for triglyceride in regulating spermatogenesis

CF Chao, YY Pesch, H Yu, C Wang, MJ Aristizabal… - Elife, 2024 - elifesciences.org
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the
contribution of neutral lipids, a major lipid group which resides in organelles called lipid …

Differential expression of brummer and levels of TAG in different developmental stages Aedes aegypti (Diptera: Culicidae), including fasted adults

LV Dos Santos, ERMN Silva, MS Caiado… - Archives of Insect …, 2024 - Wiley Online Library
Lipid storage in the form of triacylglycerol (TAG) is essential for insect life, as it enables flight,
development, and reproduction. The activity of the lipase brummer (bmm) has been shown …

Bayesian optimization of separation gradients to maximize the performance of untargeted LC-MS

H Yu, P Biswas, E Rideout, Y Cao, T Huan - bioRxiv, 2023 - biorxiv.org
Liquid chromatography (LC) with gradient elution is a routine practice for separating
complex chemical mixtures in mass spectrometry (MS)-based untargeted analysis. Despite …