A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

J Peng, M Fan, C An, F Ni, W Huang… - Basic & clinical …, 2022 - Wiley Online Library
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

Cannabinoid delivery systems for pain and inflammation treatment

N Bruni, C Della Pepa, S Oliaro-Bosso, E Pessione… - Molecules, 2018 - mdpi.com
There is a growing body of evidence to suggest that cannabinoids are beneficial for a range
of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms …

Cannabidiol for pain treatment: focus on pharmacology and mechanism of action

J Mlost, M Bryk, K Starowicz - International journal of molecular sciences, 2020 - mdpi.com
Cannabis has a long history of medical use. Although there are many cannabinoids present
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …

[HTML][HTML] Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs

LJ Gamble, JM Boesch, CW Frye… - Frontiers in veterinary …, 2018 - frontiersin.org
Objectives The objectives of this study were to determine basic oral pharmacokinetics, and
assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with …

Immune responses regulated by cannabidiol

JM Nichols, BLF Kaplan - Cannabis and cannabinoid research, 2020 - liebertpub.com
Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

DM Kopustinskiene, R Masteikova, R Lazauskas… - Antioxidants, 2022 - mdpi.com
Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

[HTML][HTML] Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis

RB Mrid, N Bouchmaa, H Ainani, R El Fatimy… - Biomedicine & …, 2022 - Elsevier
Rheumatoid arthritis (RA) is one of more than 100 types of arthritis. This chronic autoimmune
disorder affects the lining of synovial joints in about 0.5% of people and may induce severe …

Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …

EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …