Caveolae, specialized plasma membrane invaginations present in most cell types, play
important roles in multiple cellular processes including cell signaling, lipid uptake and …

Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer.
In early stages of disease the protein functions predominantly as a tumor suppressor …

Purpose: Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway
and is inhibited by ibrutinib due to covalent binding to the kinase domain. Though ibrutinib …

Duvelisib, an oral dual inhibitor of PI3K-δ and PI3K-γ, is in phase III trials for the treatment of
chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin's lymphoma. In CLL …

The aim of the present study was to investigate mechanism of the gender differences of B
cells. The results showed that 358 differential gene expressions (DEGs) were displayed …

Chronic lymphocytic leukemia (CLL) cells survive longer in vivo than in vitro, suggesting that
the tissue microenvironment provides prosurvival signals to tumor cells. Primary and …

Background Chronic lymphocytic leukemia (CLL) presents two subtypes which have
drastically different clinical outcomes, IgVH mutated (M-CLL) and IgVH unmutated (U-CLL) …

Earlier, we reported that CTLA4 expression is inversely correlated with CD38 expression in
chronic lymphocytic leukemia (CLL) cells. However, the specific role of CTLA4 in CLL …

Chronic myelogenous leukemia (CML) is characterized by the t (9; 22)(q34; q11)-associated
Bcr-Abl fusion gene, which is an essential element of clinical diagnosis. As a traditional …

In this study we investigated specific biological and clinical features associated with chronic
lymphocytic leukemia (CLL) patients carrying stereotyped BCR subset# 4 (IGHV4–34) …