Synthesis of α-aminophosphonates and related derivatives; The last decade of the Kabachnik–Fields reaction

PR Varga, G Keglevich - Molecules, 2021 - mdpi.com
The Kabachnik–Fields reaction, comprising the condensation of an amine, oxo compound
and a P-reagent (generally a> P (O) H species or trialkyl phosphite), still attracts interest due …

Divergent palladium iodide catalyzed multicomponent carbonylative approaches to functionalized isoindolinone and isobenzofuranimine derivatives

R Mancuso, I Ziccarelli, D Armentano… - The Journal of …, 2014 - ACS Publications
2-Alkynylbenzamides underwent different reaction pathways when allowed to react under
PdI2-catalyzed oxidative carbonylation conditions, depending on the nature of the external …

Isoindolinone synthesis: selective dioxane-mediated aerobic oxidation of isoindolines

P Thapa, E Corral, S Sardar, BS Pierce… - The Journal of Organic …, 2018 - ACS Publications
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of
isoindoline precursors. The transformation exhibits unique chemoselectivity for …

Practical and high stereoselective synthesis of 3-(arylmethylene) isoindolin-1-ones from 2-formylbenzoic acid

MA Reyes-González, A Zamudio-Medina, M Ordóñez - Tetrahedron Letters, 2012 - Elsevier
Practical and high stereoselective synthesis of 3-(arylmethylene) isoindolin-1-ones is
reported. The synthetic method involves the preparation of dimethyl isoindolin-1-one-3-yl …

Synthesis, characterization and in vitro bioactivity studies of isoindolin‐1‐3‐phosophonate compounds

H Jelali, IS Al Nasr, WS Koko, TA Khan… - Journal of …, 2022 - Wiley Online Library
In this work, efficient synthesis of isoindolin‐1‐one‐3‐phosphonates under catalyst‐and
solvent‐free conditions was reported to afford the desired compounds in excellent yields …

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates by a Special Kabachnik–Fields Condensation

Á Tajti, N Tóth, B Rávai, I Csontos, PT Szabó, E Bálint - Molecules, 2020 - mdpi.com
A simple and efficient microwave (MW)-assisted method was elaborated for the catalyst-free
synthesis of isoindolin-1-one-3-phosphonates by the three-component condensation of 2 …

An efficient, three-component synthesis of isoindolin-1-one-3-phosphonates under mild and solvent-free conditions

M Adib, E Sheikhi, R Yazzaf, HR Bijanzadeh… - Tetrahedron Letters, 2016 - Elsevier
An efficient and mild three-component synthesis of isoindolin-1-one-3-phosphonates is
described. The reaction between a 2-formylbenzoic acid, a primary amine, and a trialkyl …

Multicomponent Synthesis of Potentially Biologically Active Heterocycles Containing a Phosphonate or a Phosphine Oxide Moiety.

N Popovics-Tóth, E Bálint - Acta Chimica Slovenica, 2022 - search.ebscohost.com
Several multicomponent synthetic approaches were elaborated for plenty of novel nitrogen
or oxygen heterocycles containing a phosphonate or a phosphine oxide moiety. All …

Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones

N Popovics-Tóth, B Rávai, Á Tajti, B Varga… - Organic & …, 2021 - pubs.rsc.org
A new method for the synthesis of 3-oxoisoindolin-1-ylphosphine oxides bearing same or
different substituents on the phosphorus atom is described. The one-pot three-component …

A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd (OAc) 2/HCOOH system

Y Zhou, P Chen, X Lv, J Niu, Y Wang, M Lei, L Hu - Tetrahedron Letters, 2017 - Elsevier
A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives
from 2-formylbenzoic acid and amine under Pd (OAc) 2/HCOOH system has been …