Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Design of prospective antiparasitic metal-based compounds including selected organometallic cores

D Gambino, L Otero - Inorganica Chimica Acta, 2018 - Elsevier
A group of seventeen communicable and poverty-related diseases are considered
neglected by the World Health Organization due to the restricted development of diagnostic …

Synthesis and structure of new binuclear ruthenium (II) arene benzil bis (benzoylhydrazone) complexes: investigation on antiproliferative activity and apoptosis …

MSM Kasim, S Sundar, R Rengan - Inorganic chemistry frontiers, 2018 - pubs.rsc.org
A series of binuclear ruthenium (II) arene benzil bis (benzoylhydrazone) complexes (1–6) of
the common composition [(η6-arene) 2Ru2 (L) Cl2](arene= benzene or p-cymene; L= benzil …

Water-soluble mono-and binuclear Ru (η6-p-cymene) complexes containing indole thiosemicarbazones: synthesis, DFT modeling, biomolecular interactions, and in …

J Haribabu, G Sabapathi, MM Tamizh… - …, 2018 - ACS Publications
Indole thiosemicarbazone ligands were prepared from indole-3-carboxaldehyde and N-(un)
substituted thiosemicarbazide. The Ru (η6-p-cymene) complexes [Ru (η6-p-cymene)(HL1) …

Searching for new chemotherapies for tropical diseases: Ruthenium–clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma …

A Martínez, T Carreon, E Iniguez… - Journal of medicinal …, 2012 - ACS Publications
Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have
been synthesized, cis, fac-[RuIICl2 (DMSO) 3 (CTZ)](1), cis, cis, trans-[RuIICl2 (DMSO) 2 …

Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand

J Haribabu, N Balakrishnan, S Swaminathan… - Inorganic Chemistry …, 2021 - Elsevier
A water-soluble binuclear organometallic Ru-p-cymene complex [Ru (η 6-p-cymene)(η 2-L)]
2 (1) was prepared from (E)-2-((1H-indol-3-yl) methylene)-N-phenylhydrazine-1 …

The synthesis and antiparasitic activity of aryl-and ferrocenyl-derived thiosemicarbazone ruthenium (II)–arene complexes

M Adams, Y Li, H Khot, C De Kock, PJ Smith… - Dalton …, 2013 - pubs.rsc.org
A series of aryl-functionalized and ferrocenyl monothiosemicarbazone compounds (L1–L4)
were synthesized in moderate yields via a general Schiff-base condensation reaction. The …

Synthesis, characterization, antibacterial activity of thiosemicarbazones derivatives and their computational approaches: Quantum calculation, molecular docking …

M Alam, MN Abser, A Kumer, MMH Bhuiyan, P Akter… - Heliyon, 2023 - cell.com
The thiosemicarbazones and their derivatives have been recognized as antimicrobial
agents against human pathogenic bacteria and fungi. Regarding these prospective, this …

Antibacterial and antiparasitic activity of manganese (I) tricarbonyl complexes with ketoconazole, miconazole, and clotrimazole ligands

PV Simpson, C Nagel, H Bruhn… - …, 2015 - ACS Publications
Five manganese (I) tricarbonyl complexes of the general formula [Mn (CO) 3 (bpyR,
R)(azole)] PF6 with R= H, COOCH3, and azole= ketoconazole (ktz), miconazole (mcz), and …

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

P Štarha - Coordination Chemistry Reviews, 2021 - Elsevier
The development of multinuclear homometallic biologically active complexes is attractive for
modern bioinorganic chemistry, because this concept offers a multiplication of the …