Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

H Zheng, Y Liu, Y Deng, Y Li, S Liu, Y Yang, Y Qiu… - Molecular …, 2024 - Springer
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by
inflammation of the synovial tissue and joint bone destruction, often leading to significant …

Ubiquitin‐specific peptidases: Players in bone metabolism

J Shen, X Lin, F Dai, G Chen, H Lin, B Fang… - Cell …, 2023 - Wiley Online Library
Osteoporosis is an ageing‐related disease, that has become a major public health problem
and its pathogenesis has not yet been fully elucidated. Substantial evidence suggests a …

Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1

M Seeling, M Pöhnl, S Kara, N Horstmann, C Riemer… - Immunity, 2023 - cell.com
Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and
autoimmune diseases. In pooled serum IgG (IVIg), however, antibodies have a potent …

[HTML][HTML] B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging

F Wang, J Guo, S Wang, Y Wang, J Chen… - Clinical and …, 2022 - ncbi.nlm.nih.gov
Dear Editor, Skeletal aging is characterized by progressive bone loss and increased marrow
adiposity. 1, 2 Age-related bone loss impairs the exercise activity of patients and increases …

The IĸB protein BCL3 controls osteogenesis and bone health

H Jaffery, C Huesa, S Chilaka, J Cole… - Arthritis & …, 2023 - Wiley Online Library
Objective IĸB protein B‐cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐
κB family of transcription factors. NF‐κB signalling fundamentally influences the fate of bone …

Gadus morhua Eggs Sialoglycoprotein Prevent Estrogen Deficiency-Induced High Bone Turnover by Controlling OPG/RANKL/TRAF6 Pathway and Serum …

M Zhao, F Mei, J Lu, Q Xiang, G Xia, X Zhang… - Frontiers in …, 2022 - frontiersin.org
In recent years, the development of safe and effective anti-osteoporosis factors has attracted
extensive attention. In this study, an estrogen-deficient osteoporosis rat model was …

Loss of Bcl-3 delays bone fracture healing through activating NF-κB signaling in mesenchymal stem cells

F Wang, J Guo, Y Wang, Y Hu, H Zhang, J Chen… - Journal of Orthopaedic …, 2022 - Elsevier
Background Bone fracture healing is a postnatal regenerative process in which
fibrocartilaginous callus formation and bony callus formation are important. Bony callus …

I-BET151 suppresses osteoclast formation and inflammatory cytokines secretion by targetting BRD4 in multiple myeloma

NH Guo, JF Zheng, FM Zi, J Cheng - Bioscience Reports, 2019 - portlandpress.com
Background: Multiple myeloma (MM) is an incurable hematologic cancer, accompanied by
excessive osteoclast formation and inflammatory cytokine secretion. The mechanisms by …

Integrated RNA‐Seq Analysis Uncovers the Potential Mechanism of the “Kidney Governing Bones” Theory of TCM

S Yang, T Wang, J Zhang, X Leng… - … and Alternative Medicine, 2022 - Wiley Online Library
Background. As in philosophy of traditional Chinese medicine (TCM), the theory of “kidney
governing bones” has been demonstrated by a series of scientific studies. Furthermore …

TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway

XD Liu, J Zheng, S Song, ZJ Chen, YX Wang… - Adipocyte, 2023 - Taylor & Francis
Critical-size defects (CSDs) are challenging oral clinical issues that need to be solved.
Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to …