Codon usage analysis of pro-apoptotic bim gene isoforms
Background: Bim is a Bcl-2 homology 3 (BH3)-only proteins, a group of pro-apoptotic
proteins involved in physiological and pathological conditions. Both the overexpression and …
proteins involved in physiological and pathological conditions. Both the overexpression and …
Application of codon usage and context analysis in genes up-or down-regulated in neurodegeneration and cancer to combat comorbidities
Introduction Neurodegeneration and cancer present in comorbidities with inverse effects
due to the expression of genes and pathways acting in opposition. Identifying and studying …
due to the expression of genes and pathways acting in opposition. Identifying and studying …
Relative synonymous codon usage and codon pair analysis of depression associated genes
Depression negatively impacts mood, behavior, and mental and physical health. It is the
third leading cause of suicides worldwide and leads to decreased quality of life. We …
third leading cause of suicides worldwide and leads to decreased quality of life. We …
A synthetic biology approach for vaccine candidate design against delta strain of SARS-CoV-2 revealed disruption of favored codon pair as a better strategy over …
The SARS-CoV-2 delta variant (B. 1.617. 2) appeared for the first time in December 2020
and later spread worldwide. Currently available vaccines are not so efficacious in curbing …
and later spread worldwide. Currently available vaccines are not so efficacious in curbing …
[HTML][HTML] Leucine encoding codon TTG shows an inverse relationship with GC content in genes involved in neurodegeneration with iron accumulation
We determined various forces involved in shaping codon usage of the genes linked to brain
iron accumulation and infantile neuroaxonal dystrophy. The analysis paved the way for …
iron accumulation and infantile neuroaxonal dystrophy. The analysis paved the way for …
Identification and characterization of codon usage pattern and influencing factors in HFRS-causing hantaviruses
Hemorrhagic fever with renal syndrome (HFRS) is an acute viral zoonosis carried and
transmitted by infected rodents through urine, droppings, or saliva. The etiology of HFRS is …
transmitted by infected rodents through urine, droppings, or saliva. The etiology of HFRS is …
Molecular Dissection of Herpes Simplex Virus Type 1 to Elucidate Molecular Mechanisms Behind Latency and Comparison of Its Codon Usage Patterns with Genes …
P Gurjar, AA Khan, AM Alanazi… - Journal of …, 2024 - content.iospress.com
Background: Herpes simplex virus type 1 (HSV-1) is associated with Alzheimer's disease,
which goes into a cycle of latency and reactivation. The present study was envisaged to …
which goes into a cycle of latency and reactivation. The present study was envisaged to …
An investigation of codon usage pattern analysis in pancreatitis associated genes
Background Pancreatitis is an inflammatory disorder resulting from the autoactivation of
trypsinogen in the pancreas. The genetic basis of the disease is an old phenomenon, and …
trypsinogen in the pancreas. The genetic basis of the disease is an old phenomenon, and …
Codon usage is influenced by compositional constraints in genes associated with dementia
Dementia is a clinical syndrome characterized by progressive cognitive decline, and the
symptoms could be gradual, persistent, and progressive. In the present study, we …
symptoms could be gradual, persistent, and progressive. In the present study, we …
Synonymous codon variant analysis for autophagic genes dysregulated in neurodegeneration
Neurodegenerative disorders are often a culmination of the accumulation of abnormally
folded proteins and defective organelles. Autophagy is a process of removing these …
folded proteins and defective organelles. Autophagy is a process of removing these …