Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Chromothripsis is a mutational phenomenon in which a single catastrophic event generates
extensive rearrangements of one or a few chromosomes. This extreme form of genome …

Introduction Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-
related deaths worldwide with limited treatment options due to extensive radiation and …

Viral mimicry driven by endogenous double-stranded RNA (dsRNA) stimulates innate and
adaptive immune responses. However, the mechanisms that regulate dsRNA-forming …

The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-stimulator of interferon
genes (STING) pathway plays a pivotal role in innate immune responses to viral infection …

A study now finds that, after DNA damage, DNA repair by homologous recombination drives
non-immunogenic cell death during mitosis. Loss of homologous recombination allows cells …

Rat Sarcoma (RAS)-driven cancers have been one of the main foci in the field of cancer
science for over four decades. Despite significant improvement in understanding the biology …

The Senescence-Associated Secretory Phenotype (SASP), characterized by the
upregulation of inflammatory cytokines, is triggered during senescence by anti-proliferation …

Acute inflammation, characterized by a rapid influx of neutrophils, is a protective response
that can lead to chronic inflammatory diseases when left unresolved. Secretion of LTB4 …

Recent advances in isolating cells based on visual phenotypes have transformed our ability
to identify the mechanisms and consequences of complex traits. Micronucleus (MN) …