The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western
countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia,
with absolute insulin deficiency or insulin resistance as the main cause, and causes damage …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Diabetic nephropathy (DN), also named diabetic kidney disease (DKD), is a devastating
complication in patients with both type 1 and 2 diabetes mellitus (T1D and T2D) and its …

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its
pathophysiological relevance and the mechanisms that compromise adaptive ER signalling …

We recently showed that forkhead-box class O1 (FoxO1) activation protects against high
glucose–induced injury by preventing mitochondrial dysfunction in the rat kidney cortex. In …