Nemaline myopathy (NM) is among the most common non-dystrophic congenital
myopathies (incidence 1: 50.000). Hallmark features of NM are skeletal muscle weakness …

Sarcopenia–the accelerated age-related loss of muscle mass and function–is an under-
diagnosed condition, and is central to deteriorating mobility, disability and frailty in older …

INTRODUCTION Mammalian skeletal muscle harbors tissue-specific stem cells that are
triggered to replace damaged fibers after injury. Genetic ablation of satellite cells in the …

Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound
functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging …

The environmental impact of exposure to 3D-printed plastics as well as potential migration of
toxic chemicals from 3D-printed plastics remains largely unexplored. In this work we applied …

The skeletal muscle T-tubule is a specialized membrane domain essential for coordinated
muscle contraction. However, in the absence of genetically tractable systems the …

Organ growth requires a careful balance between stem cell self-renewal and lineage
commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that …

Duchenne muscular dystrophy is a severe muscle wasting disease caused by mutations in
the dystrophin gene (dmd). Ataluren has been approved by the European Medicines Agency …

The transition from notochord to vertebral column is a crucial milestone in chordate evolution
and in prenatal development of all vertebrates. As ossification of the vertebral bodies …

Muscular dystrophies (MDs) are a heterogeneous group of myopathies characterized by
progressive muscle weakness leading to death from heart or respiratory failure. MDs are …