Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

LG Ming, KM Chen, CJ Xian - Journal of cellular physiology, 2013 - Wiley Online Library
Increasingly natural products particularly flavonoids are being explored for their therapeutic
potentials in reducing bone loss and maintaining bone health. This study has reviewed …

Improvement of testicular steroidogenesis using flavonoids and isoflavonoids for prevention of late-onset male hypogonadism

LJ Martin, M Touaibia - Antioxidants, 2020 - mdpi.com
Androgen production, being important for male fertility, is mainly accomplished by the Leydig
cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis …

Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism

RK Rajan, B Balaji - Pharmaceutical biology, 2017 - Taylor & Francis
Context: Soy is the main source of phytoestrogens, which has long been used as traditional
food. One major subtype of phytoestrogens includes isoflavones and they are scientifically …

Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic …

A Hamza, MU Ijaz, H Anwar - Human & Experimental …, 2023 - journals.sagepub.com
The current research was performed to evaluate the ameliorative effects of Rhamnetin
(RHM) on polystyrene microplastics (PS-MPs)-instigated testicular dysfunction in male …

[HTML][HTML] A landscape analysis of the potential role of polyphenols for the treatment of Polycystic Ovarian Syndrome (PCOS)

R Rani, YA Hajam, R Kumar, RA Bhat, S Rai… - Phytomedicine Plus, 2022 - Elsevier
Abstract Background Polycystic Ovarian Syndrome (PCOS) is an under-recognized, under-
diagnosed and under-studied disorder; its prevalence varies between 5–26%, 6–10% of …

Inhibitors of testosterone biosynthetic and metabolic activation enzymes

L Ye, ZJ Su, RS Ge - Molecules, 2011 - mdpi.com
The Leydig cells of the testis have the capacity to biosynthesize testosterone from
cholesterol. Testosterone and its metabolically activated product dihydrotestosterone are …

Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological …

MU Ijaz, F Saher, N Aslam, A Hamza, H Anwar… - Food and Chemical …, 2023 - Elsevier
The current study was designed to evaluate the protective role of chrysoeriol against
polyethylene microplastics (PE-MP) induced testicular damage. Forty eight male rats were …

Androgen receptor and soy isoflavones in prostate cancer

MK Sivoňová, P Kaplán… - Molecular and …, 2019 - spandidos-publications.com
Androgens and androgen receptor (AR) play a critical role not only in normal prostate
development, but also in prostate cancer. For that reason, androgen deprivation therapy …

Deoxynivalenol induced spermatogenesis disorder by blood-testis barrier disruption associated with testosterone deficiency and inflammation in mice

Z Cao, W Huang, Y Sun, Y Li - Environmental pollution, 2020 - Elsevier
Deoxynivalenol (DON) is an unavoidable cereal crops contaminants and environmental
pollutants, which seriously threated the health of human and animal. DON has been …

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ54 Isomerase: A Review

MK Rasmussen, B Ekstrand… - International journal of …, 2013 - mdpi.com
This review focuses on the expression and regulation of 3β-hydroxysteroid
dehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD …