Quality and quantity control of gene expression by nonsense-mediated mRNA decay
T Kurosaki, MW Popp, LE Maquat - Nature reviews Molecular cell …, 2019 - nature.com
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes
S Lykke-Andersen, TH Jensen - Nature reviews Molecular cell biology, 2015 - nature.com
Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …
[PDF][PDF] An expanded arsenal of immune systems that protect bacteria from phages
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming
defense islands. This property enabled the recent discovery of multiple defense systems …
defense islands. This property enabled the recent discovery of multiple defense systems …
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
JA Newman, A Douangamath, S Yadzani… - Nature …, 2021 - nature.com
There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the
cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 …
cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 …
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis
Z Jia, L Yan, Z Ren, L Wu, J Wang, J Guo… - Nucleic acids …, 2019 - academic.oup.com
To date, an effective therapeutic treatment that confers strong attenuation toward
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs …
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs …
Discovery of COVID-19 inhibitors targeting the SARS-CoV-2 Nsp13 helicase
MA White, W Lin, X Cheng - The journal of physical chemistry …, 2020 - ACS Publications
The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of
people and killed several hundred thousand patients worldwide. Currently, there are no …
people and killed several hundred thousand patients worldwide. Currently, there are no …
Nonsense-mediated mRNA decay in humans at a glance
T Kurosaki, LE Maquat - Journal of cell science, 2016 - journals.biologists.com
Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …
The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …
molecule, from its production to its destruction. Whereas much has been learned about RNA …
An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and-unwinding activities
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …