Use of US Food and Drug Administration–approved substances of abuse has innate risks
due to pharmacologic and pharmacokinetic properties of the medications, but the risk when …

The potential advantage of using combination therapy is that analgesia can be maximized
while minimizing the incidence of adverse effects. In order to assess a possible synergistic …

Glutamate homeostasis and microglia activation play an important role in the development
and maintenance of neuropathic pain. So far, there has been insufficient data on the …

Hesperidin occurs in greatest concentration in plants from the Rutaceae and Lamiaceae
families. In human nutrition it contributes to the integrity of blood vessels and its deficiency in …

Drug combination for the treatment of pain is common clinical practice. Co-crystal of
Tramadol-Celecoxib (CTC) consists of two active pharmaceutical ingredients (APIs), namely …

In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-
allodynic and anti-hyperalgesic effects of these drugs, administered either separately or in …

Synergism has been used to obtain analgesia at doses at which side effects are minimal. In
addition, it has been demonstrated that inhibition of cyclooxygenase-2 is responsible for the …

The efficacy of opioids in the treatment of chronic pain is limited; however, the adverse
effects they produce are considerable. N-palmitoylethanolamide (PEA), a bioactive lipid …

Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental
equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions …

The potentiation of the antinociceptive effect of morphine by dipyrone (metamizol) and the
possible participation of a peripheral mechanism on such synergism were studied with the …