Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Removal of senescent cells (senolysis) has been proposed to be beneficial for improving
age-associated pathologies, but the molecular pathways for such senolytic activity have not …

Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific
metabolic changes remains unclear. Here we show, using the comprehensive measurement …

Volatile organic compounds play essential roles in plant environment interactions as well as
determining the fragrance of plants. Although gas chromatography-mass spectrometry …

We describe ProteomeTools, a project building molecular and digital tools from the human
proteome to facilitate biomedical research. Here we report the generation and multimodal …

Expression of PKM2, which diverts glucose-derived carbon from catabolic to biosynthetic
pathways, is a hallmark of cancer. However, PKM2 function in tumorigenesis remains …

We report XCMS-MRM and METLIN-MRM (http://xcmsonline-mrm. scripps. edu/and
http://metlin. scripps. edu/), a cloud-based data-analysis platform and a public multiple …

Data-independent acquisition (DIA) is a promising technique for the proteomic analysis of
complex protein samples. A number of studies have claimed that DIA experiments are more …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …