Cancer progress and priorities: lung cancer

MB Schabath, ML Cote - Cancer epidemiology, biomarkers & prevention, 2019 - AACR
In the United States, lung cancer is the second most common diagnosed cancer and the
leading cause of cancer-related death. Although tobacco smoking is the major risk factor …

Global patterns in excess body weight and the associated cancer burden

H Sung, RL Siegel, LA Torre… - CA: a cancer journal …, 2019 - Wiley Online Library
The prevalence of excess body weight and the associated cancer burden have been rising
over the past several decades globally. Between 1975 and 2016, the prevalence of excess …

Adiposity and cancer risk: new mechanistic insights from epidemiology

AG Renehan, M Zwahlen, M Egger - Nature Reviews Cancer, 2015 - nature.com
Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for
many common adult cancers. Over the past decade, epidemiological data have shown that …

[HTML][HTML] Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5· 24 million UK adults

K Bhaskaran, I Douglas, H Forbes, I dos-Santos-Silva… - The lancet, 2014 - thelancet.com
Background High body-mass index (BMI) predisposes to several site-specific cancers, but a
large-scale systematic and detailed characterisation of patterns of risk across all common …

Causal relationships between body mass index, smoking and lung cancer: univariable and multivariable Mendelian randomization

W Zhou, G Liu, RJ Hung, PC Haycock… - … journal of cancer, 2021 - Wiley Online Library
At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung
cancer risk, which may reflect reverse causality and confounding due to smoking behavior …

[图书][B] Handbook of Obesity--Volume 1: Epidemiology, Etiology, and Physiopathology

GA Bray - 2014 - books.google.com
In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

J Yarmolinsky, KH Wade, RC Richmond… - … Biomarkers & Prevention, 2018 - AACR
Observational epidemiologic studies are prone to confounding, measurement error, and
reverse causation, undermining robust causal inference. Mendelian randomization (MR) …

The obesity paradox in cancer: epidemiologic insights and perspectives

DH Lee, EL Giovannucci - Current nutrition reports, 2019 - Springer
Abstract Purpose of Review Controversy exists whether excess body fatness (measured by
body mass index (BMI)) is associated with better cancer survival (“obesity paradox”). Here …

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer

C Gao, CJ Patel, K Michailidou, U Peters… - International journal …, 2016 - academic.oup.com
Background: Adiposity traits have been associated with risk of many cancers in
observational studies, but whether these associations are causal is unclear. Mendelian …

Racial and ethnic differences in the epidemiology and genomics of lung cancer

MB Schabath, WD Cress, T Muñoz-Antonia - Cancer Control, 2016 - journals.sagepub.com
Background Lung cancer is the most common cancer in the world. In addition to the
geographical and sex-specific differences in the incidence, mortality, and survival rates of …