Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies

M Whitehead, S Wickremasinghe… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age
population of the developed world. DR encompasses a complex pathology, and one that is …

A review on mesenchymal stem cells for treatment of retinal diseases

S Adak, D Magdalene, S Deshmukh, D Das… - Stem cell reviews and …, 2021 - Springer
Abstract Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment
of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate …

Gene therapy and the adeno‐associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: trials, future directions and safety …

CA Ramlogan‐Steel, A Murali… - Clinical & …, 2019 - Wiley Online Library
Voretigene neparvovec‐rzyl was recently approved for the treatment of Leber congenital
amaurosis, and the use of gene therapy for eye disease is attracting even greater interest …

Updates on gene therapy for diabetic retinopathy

JH Wang, GE Roberts, GS Liu - Current Diabetes Reports, 2020 - Springer
Abstract Purpose of Review Diabetic retinopathy (DR), a leading cause of visual impairment
in the developed country, is characterized by vascular lesions and neuronal damage of the …

Unconventional avenues to decelerate diabetic retinopathy

B Takkar, A Sheemar, R Jayasudha, D Soni… - Survey of …, 2022 - Elsevier
Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus
(DM), causing significant visual impairment worldwide. Current gold standards for retarding …

AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies

BFM Castro, JC Steel, CJ Layton - BioDrugs, 2024 - Springer
Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vascular
diseases with high prevalence, ranking among the leading causes of blindness and vision …

Long term features of diabetic retinopathy in streptozotocin-induced diabetic Wistar rats

A Naderi, R Zahed, L Aghajanpour, FA Amoli… - Experimental Eye …, 2019 - Elsevier
Diabetic retinopathy is a complication of diabetes and a leading cause of vision loss among
working-age adults. To assess whether the Wistar rat with Streptozotocin (STZ)-induced …

Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes

C Clapp, N Diaz-Lezama, E Adan-Castro… - Acta …, 2019 - Springer
Aims Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis
involves inflammation, pathological angiogenesis, neuronal and glial dysfunction. The …

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

D Arredondo Zamarripa, R Noguez Imm… - Scientific reports, 2017 - nature.com
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other
chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing …

Sulpiride‐induced hyperprolactinaemia increases retinal vasoinhibin and protects against diabetic retinopathy in rats

E Adán‐Castro, L Siqueiros‐Márquez… - Journal of …, 2022 - Wiley Online Library
Excessive vasopermeability and angiogenesis compromise vision in diabetic macular
oedema (DME) and diabetic retinopathy (DR). Vasoinhibin is a fragment of the hormone …